The rune enhances your stats when it is in the staff. You obtain runes by eliminating monsters or buying them in a store.

Rune types

Rune of Damage
Rune of Accuracy
Rune of Theft
Rune of HP Regen
Rune of HP
Rune of Crit DMG

You can enhance your runes by leveling them up. The level increases through the merge of other runes. During the merge, the rune accumulates energy when its level rises sufficiently. You can use runes of any level for the merge. Some of the energy accumulated before will go into the progress of the upgraded rune.